Remember I said, you don't need the progestin.

记得说过，你不需要孕激素。

We also look at the progestin component of the oral contraceptive pill, because we have four generations of progesterone.

们还研究了口服避孕药的孕激素成分，因为孕激素有四代。

And you know, but all of the studies that have been done really basically are with estrogen and progestin.

你知，所有已进行的研究基本上都是关于雌激素和孕激素的。

We see that women who start taking it midlife are complaining about it, but it's actually a progestin driven thing.

们看到那年时期开始服用它的女性会抱怨，实际上这是由孕激素驱动的。

You know, we believe that the progestins, which are slightly different molecules than progesterone, carry the higher breast cancer risk.

你知，们认为那与孕酮分子略有不同的孕激素携带了更高的乳腺癌风险。

Now, for women who've had hysterectomies and don't need to have the progestin, you can just take estrogen alone.

对于已经接受子宫切除手术且无需服用孕激素的女性，可以单独使用雌激素。

Because remember, estrogen and progestin go together.

因为请记住，雌激素和孕酮是相辅相成的。

So, significant mood issues because that progestin has a direct effect on a lot of the dopamine receptors in the brain as well.

所以，显着的情绪问题是因为孕激素直接作用于大脑的许多多巴胺受体。

That the hormone progesterone is lower risk and that if you don't need a progesterone or a progestin, that that risk is the lowest.

那黄体酮激素的风险较低， 如果你不需要黄体酮或孕激素，那么风险就是最低的。

So we know that estrogen plus a progestin is associated with an increased risk of breast cancer, but those aren't the hormones that we typically prescribe now.

所以们知， 雌激素加上孕激素会增加乳腺癌的风险，这并不是们现通常开的激素。

And the arm with estrogen plus, so when it was Premarin that was used, Premarin plus progestin, that was stopped early because they reached the threshold of concern about breast cancer.

而使用雌激素的那一组， 当使用的是Premarin加上孕激素时，由于达到了对乳腺癌担忧的阈值， 所以提前停止了试验。

So we're coming back around to understanding that maybe there should be more to hormone replacement therapy than just estrogen and progestin, but we need a lot more studies about that.

因此， 们重新认识到， 激素替代疗法可能不仅仅需要雌激素和孕激素，还需要更多关于这方面的研究。

So, as we sort of got more women who were taking hormones, we found that there were some tweaks that need to be made along the way and added the progestin component to it.

于是， 随着更多服用激素的女性加入，们发现过程需要做一调整， 并加入了孕激素成分。

Yes, hormone replacement therapy, typically it is comprised of estrogen, which is the secret sauce in hormone replacement therapy, and a progestin, which is the second hormone that you take when you have an intact uterus.

是的， 激素替代疗法通常由雌激素组成，这是激素替代疗法的关键成分，以及孕激素， 这是当你拥有完整子宫时服用的第二种激素。