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Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryon...

DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease.

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经济学人-科技

The consequence is to inactivate the gene being methylated.

作用将使甲因失去活性。

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科学60秒-科学美国人 2020年11月合集

As we age, some stretches of DNA get more methylated, and others less.

随着年龄增长,一DNA片段程度会上升,而另一则会下降。

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经济学人-科技

Newborns whose mothers suffered from depression while they were pregnant are known to have more highly methylated glucocorticoid-receptor genes than others.

新生儿母亲若是在怀孕期间现抑郁症状,他们糖皮质激素受体程度就会比其他新生儿更高。

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Osmosis-遗传

Translocations can disrupt SNRNP and move the small nucleolar RNA genes away from their imprinting center, causing them to get methylated and turned off.

SNRNP因易位会破坏小核内核糖核蛋白(SNRPN),并将核仁小RNA因移印记中心,导致沉默。

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Osmosis-遗传

If the paternal imprinting center is mutated, the region gets methylated and those genes get turned off, meaning that both the maternal and paternal genes are silenced.

如果父源印记中心突变,因将被甲沉默,导致母源和父源因都处于沉默状态。

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TED-Ed(视频版)

In one famous experiment, when mother rats weren't attentive enough to their pups, genes in the babies that helped them manage stress were methylated and turned off.

在一个着名实验中,当母老鼠对它们幼崽不够关心情况下,幼崽体内帮助它们管理压力因甲并且隐藏了。

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Osmosis-遗传

If both copies of chromosome 15 were derived from the mother, that means all the prader willi genes are methylated and silenced, since there's no unsilenced paternal genes.

如果15号染色体两条同源染色体都来自母方,就意味着所有普拉德-威利因都被甲沉默,根本就没有父源表达。

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