Lumbar puncture is classified as a relative contraindication in individuals with suspected increased intracranial pressure due to possible herniations.

腰椎穿刺，对于疑似因脑疝引起颅内压增高患者，是一种相对禁忌症。

That is not a contraindication to HRT.

这不是HRT禁忌症。

For every medicine that you give, there is an indication, and there's a contraindication.

每种药物都有其适应症和禁忌症。

What about in terms of any potential contraindications for any of your products?

关于您产品，是否在任何潜在使用禁忌呢？

When you're under 60 and you don't have any of those absolute contraindications, it's really a window of opportunity.

当你未满60岁并且没有那些绝对禁忌症时，这其实是一个很好机。

There would be a contraindication if a perfect being did exist and we denied that such a being was omnipotent.

如果一个完美在实在，就有一个禁忌症，而我们否认这在是全能。

And as a matter of fact, not only is it not a contraindication to HRT, to estrogen therapy, I should say, because you've had a hysterectomy.

事实上，这不仅不是激素替代疗法（HRT）或我应该说是雌激素治疗禁忌症，因为你已经做了子宫切除术。 记得我提到过， 你不需要孕激素。

One thing that we didn't talk about is one of the contraindications for starting estrogen is being more than 10 years from your last period or over the age of 60.

我们没有谈到一点是，开始服用雌激素一个禁忌症是距离你最后一次月经超过10年或年龄超过60岁。

Second-line immunotherapy Immunotherapy can still be used as second-line treatment in patients who were managed cautiously in the frst-line setting because of a relative contraindication to immunotherapy or poor PS at that time.

二线免疫治疗 对于因免疫治疗相对禁忌症或当时 PS 较差而在一线环境中谨慎处理患者，免疫治疗仍可用作二线治疗。

So all options are on the table, but in terms of going through, I'll review it as an option, the evidence, but also reinforcing personal choice, but also medical evaluation just to make sure there's not contraindications.

所以所有选项都在考虑范围内， 但在具体实施时，我将其作为一个选项进行评估， 包括证据，同时也强化个人选择，并进行医学评估以保没有禁忌症。

First-line chemotherapy alone For patients who have relative contraindications to upfront immunotherapy or PS worse than 1, a histology-appropriate platinum- doublet chemotherapy may be used (see above), with or without bevacizumab added for those with non-squamous histology.

仅一线化疗 对于前期免疫治疗有相对禁忌症或 PS 低于 1 患者，可以使用适合组织学铂类双药化疗（见上文），对于非鳞状组织学患者，可加用或不加用贝伐珠单抗。

The only reasons, the only contraindications that we have for HRT are if you personally have breast cancer or an estrogen-dependent cancer such as endometrial cancer, if you have undiagnosed vaginal bleeding, if you currently have a heart attack.

我们之所以不推荐使用HRT唯一原因， 即唯一禁忌症， 是您个人患有乳腺癌或依赖雌激素癌症（如子宫内膜癌），或者在未诊阴道出血，以及目前正在经历心脏病发作。 这里强调是您本人当前健康状况， 而非家族中曾有心脏病发作或中风病史。